Homocysteine and MTHFR – What are your results?

As noted in our last blog, Dr. Dale Bredesen, a famous neurologist  has developed a comprehensive program to halt or even reverse dementia. One of the significant factors that can affect cognition is homocysteine which is a sulfur containing amino acid and is a byproduct of methionine metabolism. Methionine is an essential amino acid that is a building block for protein synthesis.

High levels of homocysteine can cause damage to the walls of blood vessels causing thrombosis (clotting) and plugging. This lack of blood flow can cause tiny areas of cell death leading to cognitive issues, as well as cardiovascular disease-yet most people have no idea what their homocysteine level is as it is not part of conventional screening blood tests. 

Research has shown that the MTHFR gene (methylenetetrahydrofolate reductase) encodes an enzyme that is crucial for the metabolism of homocysteine to methionine. This conversion requires folate (Vitamin B9). There are 2 common variants  that commonly occur – the 1298C and 677T polymorphisms. Reduced MTHFR gene activity from these variants lead to elevated homocysteine levels and secondary vascular damage. The fix for these genetic abnormalities is quite simple-optimize your levels of vitamins B12, B9 and B6 (pyridoxine) by eating more green leafy vegetables and legumes. Another way to approach this issue is to supplement with 1000 mcg B12 and 800 mcg of folate. Usually supplemental Vitamin B6 is not recommended as high doses can lead to peripheral nerve damage.

It is interesting that individuals with the 677T polymorphism may have an increased risk of depression and anxiety. This seems to be due to the impact of reduced MTHFR enzyme activity on folate (vitamin B9) metabolism and the subsequent effects on brain neurotransmitter synthesis and function!

Getting tested for homocysteine and vitamin levels as well as MTHFR gene mutations is simple by using a blood test and we recommend it for almost all our patients. Interested in getting MTHFR gene testing? Contact us here.